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quiz
what is the average diameter of a normal erythrocyte? | 7-8 nm |
what disease state can be associated with the presence of tissue neutrophils in bone marrow? | Myelocytic leukemia |
which cell in the granulocytic series is present in greatest percentages in normal bone marrow? | band neutrophil |
where does T-cell differentiation take place? | thymus |
the stage in granulocyte maturation where the nucleus appears kidney shaped is evident in what cell? | metamyelocyte |
By increasing hematopoiesis, the hematopoietic system can respond to stimuli such as: | infection, bleeding, hyopoxia |
reactive lymphocytes are present in the evaluation of certain diseases such as: | infectious mononucleosis |
the maturation of the granulocytic series is characterized by | decrease in nuclear volume, appearance and disappearance of primary granules, nuclear chromatin clumping, cytoplasmic color change from blue to pink appearance of secondary granules |
the lymphoblast can be identified morphologically by what characteristics? | large round nucleus, basophilic cytoplasm, nucleoli |
what percentage of erythrocytes is functional in peripheral blood after release from the bone marrow | 100% |
Plasmacytes represent the end stage of what cell lineage? | lymphocytes |
which of the following is the largest hematopoietic cell in the bone marrow? | megakaryocyte |
what stages do both basophils and eosinophils pass through in their sequence of maturity? | Myelocyte, metamyelocyte, band cell, segmented cell |
Evaluate the clinical use of interleukins | wound healing, activating lymphocytes, assisting in growth of bone marrow |
the hematopoietic system consists of the | thymus, bone marrow, liver, spleen |
what is the sequence of maturity for the erythrocyte? | Rubriblast, prorubricyte, rubricyte, metarubricyte, reticulocyte, erythrocyte |
the platelet structure is composed of | Peripheral zone, Sol-gel zone, Organelle zone |
platelet membrane glycoprotein Ib is the receptor for __________, which serves to mediate the adhesion of platelets to subendothelium | von Willebrand factor |
which of the following include specificity of plasma membrane receptors within the peripheral zone?> | ADP, Thrombin, Glycoprotein IIa, Serotonin |
all of the following are major systems involved in maintaining hemostasis EXCEPT | Kinin system |
The organelle zone is composed of | Alpha granules, Dense granules, Lysosomes, Glycogen |
What characteristics are helpful in the identification of monocytes? | gray-blue cytoplasm, digestive vacuoles, lacy, delicate chromatin and indented nucleus, ground-glass appearnce of cytoplasm with evenly distributed fine granules |
which constituent of the peripheral zone contain glycoproteins responsible for blood group specificity[ABO], tissue compatibility [human leukocyte antigen [HLA]], and platelet antigenicity? | Glycocalyx |
Primary hemostasis is defined as: | The interaction of platelets and the vascular wndothelium in halting bleeding following vascular injury |
what is the function of tissue thromboplastin in maintaining vascular integrity? | initiates fibrin formation through the extrinsic pathway of the coagulation system. |
________ is a reversible process whereby platelets stick to a foreign surface | adhesion |
what is the normal platelet count? | 150,000 to 400,000/uL |
Platelet factor4 [PF4] neutralizes which anticoagulant? | heparin |
activation of platelets results in which of the following? | stickiness, adhesion, shape change, aggregation |
The platelet membrane represents a fluid lipid bilayer composed of | glycoproteins, glycolipids, lipoproteins |
the clear zone of cytoplasm that surrounds a higher stained granulomere is termed | Hyalomere |
what is the function of tissue plasminogen activator [TPA]? | activates plasminogen to plasmin and lyses the fibrin clot |
The peripheral blood, approximately _______ percent of the platelets are sequenstered in the spleen as functional reserves. | 30% |
what major contractile protein in the platelet cytosol accounts for 20-30% of total platelet protein and functions within microtubules in organizing parallel filaments capable of contraction? | actin |
the average diameter of the platelet is | 2-4 nm |
the organelle region is responsible for the ______ activities of the platelet | metabolic |
Hemorrgaging from veins results in large, ill-defiend, soft tissue bleeding termed | Ecchymoses |
which substance induces dense and alpha granule secretion? | Thromboxane A2 [TXA2], ADP, Epinephrine, Thrombin |
Which of the following is the largest hematopoietic cell in the bone marrow?
Granular megakaryocytes are the largest hematopoietic cells in the bone marrow. The duration from formation of megakaryoblasts to platelet production is about 1 week. Platelets are released into the bloodstream with a proportion [approximately one-third] pooled in the spleen.
What are the largest cells in the bone marrow?
nucleus] of cells known as megakaryocytes, the largest cells of the marrow. Within the marrow the abundant granular cytoplasm of the megakaryocyte divides into many small segments that break off and are released as platelets into the circulating blood.
What are the hematopoietic cells in bone marrow?
An immature cell that can develop into all types of blood cells, including white blood cells, red blood cells, and platelets. Hematopoietic stem cells are found in the peripheral blood and the bone marrow. Also called blood stem cell.
What are the 2 main hematopoietic stem cells?
Blood cells from HSCs are divided into two lineages: lymphoid cells and myeloid cells [7].