How does adrenaline work in anaphylaxis?
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Allergy & ENT Associates provide specialized care for the diagnosis and management of all types of allergies for patients throughout the greater Houston area such as Clear Lake, Katy, Kingwood, and many more. We employ a team of experienced doctors and support staff who will find a treatment plan that works for you.
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Adrenaline is a hormone that helps you react very quickly if you are faced with an exciting, stressful or dangerous situation. This is known as the ‘fight-or-flight response’. In this type of situation, your brain sends messages to your adrenal glands (located just above the kidneys) to start releasing the hormone into the blood. You will feel the effects of the adrenaline within 2 or 3 minutes. Adrenaline is also a medication used to treat a severe allergic reaction (anaphylaxis) in an emergency. It may also be used during cardiac arrest, croup and asthma when other treatments are not effective. When the situation becomes calmer, the glands stop producing adrenaline. You might still feel the effects of it though, for up to 1 hour. The dose can be given using an autoinjector, and you can read about how to use an adrenaline autoinjector here. If someone is having an anaphylaxis, give the adrenaline first then call triple zero (000) and ask for an ambulance. What is the role of adrenaline?Adrenaline makes your heart beat faster and your lungs breathe more efficiently. It causes the blood vessels to send more blood to the brain and muscles, increases your blood pressure, makes your brain more alert, and raises sugar levels in the blood to give you energy. Your pupils grow larger and you sweat. When you have a lot of adrenaline in your blood, you don’t feel as much pain, so you can keep running or fighting, even if you are injured. It makes you stronger and allows you to perform better. The body also produces a similar chemical called noradrenaline (or norepinephrine). It is made in the nervous system and released into the blood continuously. Unlike adrenaline, which affects several parts of the body, noradrenaline’s main role is to control blood pressure. Noradrenaline is also used to treat people whose hearts have stopped beating (cardiac arrest). It can be used along with other medicines to control pain before or during surgery. Is having too much or too little adrenaline a problem?If you have too much adrenaline, it can lead to symptoms including: Being stressed can lead to someone having too much adrenaline. Some rare medical conditions, such as a tumour on the adrenal glands, can also cause someone to have too much adrenaline. Over time, high levels of adrenaline can increase your risk of a heart attack or stroke, and cause heart palpitations, high blood pressure, anxiety and weight loss. Having too little adrenaline is very rare, but people who don’t have enough of the hormone cannot react properly to stressful situations. How can I adjust my adrenaline levels?If you are stressed, you can lower the adrenaline level in your body by:
It also helps to eat a healthy diet, exercise regularly and limit caffeine and alcohol. Adrenaline injectionsAn adrenaline injection, such as EpiPen or Adrenaline Mylan, is used as a treatment for a severe allergic reaction (anaphylaxis). It works by quickly reducing swelling in the throat, opening up the airways and preventing the blood pressure from falling too low. It is sometimes used for people who have serious breathing problems including asthma with associated anaphylaxis, croup and cardiac arrest. The adrenaline is injected into the large muscle in the thigh and can save someone’s life. If in doubt, always use the adrenaline autoinjector first, then use asthma reliever medicine and call triple zero (000) for an ambulance. There are 2 doses of adrenaline autoinjector available in Australia and New Zealand:
For more information on adrenaline autoinjectors, including videos on how to use them, visit the ASCIA website. If you are at risk of anaphylaxis, it is a good idea to discuss an 'anaphylaxis action plan' with your doctor or pharmacist. Side effects associated with adrenaline's alpha and beta receptor activity may include palpitations, tachycardia, and hypertension as well as undesirable effects on the central nervous system, sweating, nausea and vomiting, respiratory difficulty, pallor, dizziness, weakness, tremor, headache, apprehension, nervousness and anxiety. Cardiac arrhythmias may follow administration of adrenaline.2,3 There is no known reason why anyone should not use EpiPen® during an allergic emergency.2,3 EpiPen is considered first aid treatment for anaphylaxis only. Patients should be advised to call 999, ask for an ambulance and say 'anaphylaxis' as soon as they experience symptoms. What is the mechanism of action for adrenaline?Mechanism of Action
Through its action on alpha-1 receptors, epinephrine induces increased vascular smooth muscle contraction, pupillary dilator muscle contraction, and intestinal sphincter muscle contraction.
Why adrenaline is used in anaphylactic shock?Adrenaline has physiological benefits in the treatment of anaphylaxis: stimulation of α adrenoceptors increases peripheral vascular resistance thus improving blood pressure and coronary perfusion, reversing peripheral vasodilation, and decreasing angioedema.
What is the main action of adrenaline epinephrine in anaphylaxis?Adrenaline is the most important drug for the treatment of anaphylaxis. Adrenaline maintains blood pressure, restores adequate tissue oxygenation and causes bronchodilation. Adrenaline works best when given early after the onset of anaphylaxis symptoms.
How does epinephrine work in allergic reaction?For severe allergic reactions which lead to hypotension, epinephrine helps to increase blood flow through veins by constricting blood vessels. By binding to receptors on smooth muscles of the lungs, epinephrine helps to relax the muscles blocking the airways and allows breathing to return to normal.
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