What is the problem with the ends of linear eukaryotic chromosomes how does telomerase help the issue?
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Show Why are the ends of eukaryotic chromosomes vulnerable How do telomeres help?Obviously, intact telomeres are essential for chromosome integrity [37-39]. Therefore, telomere associated proteins protect the ends of eukaryotic chromosomes from being recognized as double strand breaks, and avoid chromosome end degradation by nucleases and non-canonical chromosome-end fusions.
How does telomerase solve the end problem?Telomerase adds complementary RNA bases to the 3′ end of the DNA strand. Once the 3′ end of the lagging strand template is sufficiently elongated, DNA polymerase adds the complementary nucleotides to the ends of the chromosomes; thus, the ends of the chromosomes are replicated.
What is the importance of telomerase in the challenge of replicating the ends of linear chromosome?Telomerase is a large ribonucleoprotein complex responsible for progressive synthesis of telomeric DNA repeats (TTAGGG) at the 3′ ends of linear chromosomes, thereby reversing the loss of DNA from each round of replication.
How do telomeres protect the ends of chromosomes?Telomeres are how cells protect chromosome ends. The telomere itself is a long stretch of a specific short DNA sequence repeated over and over hundreds of times. At the very end of the telomere is a sort of knot not called the "T-loop," which keeps the chromosome ends from all sticking together.
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