What is the major difference in the action of a water soluble hormone versus a lipid soluble hormone?
Class I nuclear receptor (NR) mechanism of action. Show Hormone binding to the NR triggers dissociation of heat shock proteins (HSP), dimerization, and translocation to the nucleus, where the NR binds to a specific sequence of DNA known as a hormone response element (HRE). The nuclear receptor DNA complex in turn recruits other proteins that are responsible for transcription of downstream DNA into mRNA, which is eventually translated into protein, which results in a change in cell function.
What is the major difference in the action of a water soluble hormone versus a lipid soluble hormone quizlet?What are two major differences between the actions of lipid-soluble hormones and water-soluble hormones? Lipid-soluble hormones bind to receptors inside the cell; water-soluble hormones bind to plasma membrane receptors.
What are lipid soluble and water soluble hormones?Water-soluble hormones generally bind to extracellular targets on the plasma membrane. Hormones such as estrogen, testosterone, progesterone, cortisol, and those produced in the thyroid are fat-soluble and repel water (hydrophobic). Fat-soluble hormones "like" lipid structures such as cell and nuclear membranes.
What is the action of lipid soluble hormones?Lipid-derived (soluble) hormones can enter the cell by diffusing across the plasma membrane and binding to DNA to regulate gene transcription and to change the cell's activities by inducing production of proteins that affect, in general, the long-term structure and function of the cell.
|